IACUC Protocol Drafter

---

name: iacuc-protocol-drafter

description: Draft IACUC protocol applications with focus on the 3Rs principles justification

version: 1.0.0

category: Pharma

tags: []

author: AIPOCH

license: MIT

status: Draft

risk_level: Medium

skill_type: Tool/Script

owner: AIPOCH

reviewer: ''

last_updated: '2026-02-06'

---

# IACUC Protocol Drafter

**ID**: 105

**Name**: IACUC Protocol Drafter

**Description**: Draft Institutional Animal Care and Use Committee (IACUC) protocol applications, especially the justification section for the "3Rs principles" (Replacement, Reduction, Refinement).

Requirements

Usage

# Generate local file
python skills/iacuc-protocol-drafter/scripts/main.py --input protocol_input.json --output iacuc_protocol.txt

# Use stdin/stdout
cat protocol_input.json | python skills/iacuc-protocol-drafter/scripts/main.py

Parameters

| Parameter | Type | Default | Required | Description |

|-----------|------|---------|----------|-------------|

| `--input`, `-i` | string | - | Yes | Path to input JSON file with protocol details |

| `--output`, `-o` | string | stdout | No | Output file path for generated protocol |

| `--template` | string | standard | No | Template type (standard, minimal, detailed) |

| `--format` | string | text | No | Output format (text, markdown, docx) |

Input Format (JSON)

{
  "title": "Experiment Title",
  "principal_investigator": "Principal Investigator Name",
  "institution": "Research Institution Name",
  "species": "Experimental Animal Species",
  "number_of_animals": 50,
  "procedure_description": "Brief description of experimental procedures",
  "pain_category": "B",
  "justification": {
    "replacement": {
      "alternatives_considered": ["In vitro experiments", "Computer simulation"],
      "why_animals_needed": "Reasons why animals must be used"
    },
    "reduction": {
      "sample_size_calculation": "Sample size calculation method and rationale",
      "minimization_strategies": "Strategies to minimize animal numbers"
    },
    "refinement": {
      "pain_management": "Pain management measures",
      "housing_enrichment": "Housing environment optimization",
      "humane_endpoints": "Humane endpoint setting"
    }
  }
}

Output

Generate IACUC-standard application text, including a complete 3Rs principles justification section.

Templates

Built-in standard templates cover:

Notes

Risk Assessment

| Risk Indicator | Assessment | Level |

|----------------|------------|-------|

| Code Execution | Python/R scripts executed locally | Medium |

| Network Access | No external API calls | Low |

| File System Access | Read input files, write output files | Medium |

| Instruction Tampering | Standard prompt guidelines | Low |

| Data Exposure | Output files saved to workspace | Low |

Security Checklist

Prerequisites

No additional Python packages required.

Evaluation Criteria

Success Metrics

Test Cases

1. **Basic Functionality**: Standard input → Expected output

2. **Edge Case**: Invalid input → Graceful error handling

3. **Performance**: Large dataset → Acceptable processing time

Lifecycle Status

- Performance optimization

- Additional feature support