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// Skill profile

Pharma IP Expansion Agent

Name: Pharma IP Expansion Agent
Author: cheminem

name: pharmaclaw-ip-expansion-agent

by cheminem · published 2026-03-22

API集成自动化任务加密货币

Total installs

Stars

★ 0

Last updated

2026-03

// Install command

$ claw add gh:cheminem/cheminem-pharmaclaw-ip-expansion-agent

View on GitHub

// Full documentation

---

name: pharmaclaw-ip-expansion-agent

description: >-

Intellectual Property Expansion Agent for pharma drug discovery/development teams.

Proactively manages/expands IP portfolios by analyzing SMILES/molecules from other agents

(Drug Discovery/Synthesis), performing infringement/FTO analyses via RDKit similarity & patent APIs,

mining prior art for novelty suggestions (bioisosteres/derivatives), and recommending strategic claims.

Triggers on: IP/patent/FTO/infringement/novelty/prior art queries for molecules/SMILES/therapeutics;

portfolio tracking; chaining with chemistry-query/Tox/Safety agents.

Use for patentable derivative ideas, risk matrices, white space identification, expiration monitoring.

---

# Pharma IP Expansion Agent

Specialized agent extending pharma team agents (Drug Discovery, Synthesis via chemistry-query, Patent/Literature/Tox/Safety).

Analyzes inputs (SMILES, keywords, profiles) for actionable IP insights: portfolio mgmt, infringement/FTO, prior art novelty,

strategic expansion. Outputs JSON/MD reports + RDKit viz (PNG/SVG).

Core Capabilities

Follow workflow: Parse input → Analyze → Generate report → Log to portfolio DB.

1. **Portfolio Management**: Track assets (patents/apps), monitor expirations. Use `scripts/agent.py track`.

2. **Infringement Analysis**: RDKit Morgan FP Tanimoto (>0.8 flag risk) vs patent compounds.

3. **FTO Assessments**: USPTO/PubChem searches for blocking patents in area.

4. **Prior Art Mining/Novelty**: NLP extract claims/chemicals → suggest RDKit bioisosteres evading art.

5. **Strategic Expansion**: Recommend continuations/repurposing based on trends.

Quick Start

Exec main agent:

python3 scripts/agent.py --mode analysis --input '{"smiles": ["CCO"], "from_agent": "synthesis", "therapeutic": "pain"}'

Output: JSON report w/ risks, suggestions, viz saved to assets/.

For multi-agent chaining (OpenClaw): Spawn sub-session w/ this skill active, pass JSON from chemistry-query.

Workflow Decision Tree

**Input JSON/SMILES?** → RDKit parse → Fingerprint → Compare patents (scripts/rdkit_utils.py)

**Portfolio query?** → SQLite query (self.db)

**FTO/Prior art?** → API fetch → NLP parse (references/nlp_patterns.md) → Similarity

**Strategic?** → Market trends via PubChem stats + derivatives

**Edge: Intl/PCT/AI-inv?** → Note variations, flag enablement risks.

Always output structured JSON: `{"risks": [...], "suggestions": [...], "viz_path": "report.png", "recommendations": {...}}` + MD report.

Multi-Agent Integration (OpenClaw)

Input from Synthesis/chemistry-query: `{"smiles": [...], "reactions": [...]}` → Auto infringement check.

Chain w/ Tox/Safety: Incorporate ADMET/safety to prioritize claims.

Spawn: `sessions_spawn task="IP expand this SMILES from synth: ..."`

Autonomous: Cron portfolio checks.

Resources

scripts/

`agent.py`: Main class IPExpansionAgent w/ all methods. Exec directly or import.

`rdkit_utils.py`: FP/similarity/bioisosteres.

`patent_fetch.py`: USPTO/PubChem APIs.

`nlp_extract.py`: Claims/chem names (spaCy).

Test: `python3 scripts/agent.py --help`

references/

`apis.md`: USPTO/EPO/PubChem endpoints.

`rdkit_guide.md`: FP radii, Tanimoto thresholds.

`ip_strategies.md`: Claims types, FTO best practices.

`pharma_trends.md`: AI-IP, PCT notes.

Load via `read references/apis.md` for API details.

assets/

`report_template.md`: MD report format.

`portfolio_schema.sql`: DB init.

`risk_matrix_template.svg`: Editable viz.

Copy to outputs.

Implementation Notes

DB: SQLite `ip_portfolio.db` (assets/portfolio_schema.sql).

Thresholds: Tanimoto>0.85 high risk; configurable.

Viz: RDKit PNG/SVG to current dir.

Deps: `pip install rdkit-pypi requests pandas sqlite3 spacy scispacy` (assume chemistry env).

Logging: To `logs/ip_expansion.log`.

OpenClaw: Use `exec` on scripts/ for analysis; `write` reports.

For updates, edit class methods.

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