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// Skill profile

Clarity Clinical Skill

Name: Clarity Clinical Skill
Author: clarityprotocol

name: clarity-clinical

by clarityprotocol · published 2026-03-22

数据处理API集成加密货币

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★ 0

Last updated

2026-03

// Install command

$ claw add gh:clarityprotocol/clarityprotocol-clarity-clinical

View on GitHub

// Full documentation

---

name: clarity-clinical

description: >

Query clinical variant data from ClinVar and gnomAD via Clarity Protocol.

Use when the user asks about ClinVar classification, clinical significance,

pathogenicity, gnomAD frequency, population genetics, or clinical data for gene.

Capabilities: search clinical variants by gene, get detailed variant annotations.

license: MIT

compatibility: Requires internet access to clarityprotocol.io. Optional CLARITY_API_KEY env var for 100 req/min (vs 10 req/min).

metadata:

author: clarity-protocol

version: "1.0.0"

homepage: https://clarityprotocol.io

---

# Clarity Clinical Skill

Access clinical variant annotations from ClinVar and population frequency data from gnomAD through Clarity Protocol's integrated database.

Quick Start

List all clinical variants:

python scripts/query_clinical.py

Filter by gene symbol:

python scripts/query_clinical.py --gene-symbol MAPT

Get details for a specific variant:

python scripts/query_clinical.py --gene MAPT --variant NM_005910.6:c.926C>T

Get variant details in readable format:

python scripts/query_clinical.py --gene MAPT --variant NM_005910.6:c.926C>T --format summary

Clinical Variant Fields

Each clinical variant includes:

`gene_symbol`: HGNC gene symbol

`variant_notation`: Full HGVS notation (transcript-based)

`clinvar_significance`: Clinical significance classification (e.g., "Pathogenic", "Benign")

`clinvar_review_status`: Review status stars (e.g., "criteria provided, multiple submitters")

`clinvar_last_evaluated`: Date of last ClinVar evaluation

`gnomad_af`: Allele frequency in gnomAD (population prevalence)

`gnomad_ac`: Allele count in gnomAD

`gnomad_an`: Total allele number in gnomAD

`fetched_at`: When this data was retrieved from ClinVar/gnomAD

ClinVar Significance Values

**Pathogenic**: Strong evidence for disease causation

**Likely pathogenic**: Moderate evidence for disease causation

**Benign**: Strong evidence of no disease causation

**Likely benign**: Moderate evidence of no disease causation

**Uncertain significance**: Insufficient evidence

**Conflicting interpretations**: Disagreement among submitters

gnomAD Frequency Interpretation

**af < 0.0001**: Very rare (< 0.01%)

**af < 0.001**: Rare (< 0.1%)

**af < 0.01**: Uncommon (< 1%)

**af >= 0.01**: Common (>= 1%)

Rate Limits

**Anonymous (no API key)**: 10 requests/minute

**With API key**: 100 requests/minute

To use an API key, set the `CLARITY_API_KEY` environment variable:

export CLARITY_API_KEY=your_key_here
python scripts/query_clinical.py --gene-symbol MAPT

Get your API key at https://clarityprotocol.io

Error Handling

**404 Not Found**: The specified gene/variant combination does not exist in the clinical database.

**429 Rate Limit**: You've exceeded the rate limit. The script will display how long to wait.

**500 Server Error**: The API server encountered an error. Try again later.

**Timeout**: The request took longer than 30 seconds.

Pagination

Clinical variant lists are paginated. The API returns a `next_cursor` field if more results are available.

Use Cases

Check if a variant is pathogenic in ClinVar

Get population frequency data for a mutation

Compare clinical significance across variants in a gene

Assess variant review status quality

Filter common vs. rare variants using gnomAD

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